Also known as: TXA, Trans-4-(Aminomethyl)Cyclohexane-1-Carboxylic Acid
Tranexamic acid is a synthetic lysine derivative originally used medically to reduce bleeding. In skincare, it inhibits plasmin-mediated activation of melanocytes, reducing melanin production through a unique pathway. It is effective for melasma and post-inflammatory hyperpigmentation, and is well-tolerated by sensitive skin. A newer brightening active with growing clinical evidence.
Comedogenicity ratings are based on the rabbit ear assay model. Individual skin responses vary. See our article on comedogenicity ratings for context.
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